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AMPHETAMINE (AMP) |
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 Amphetamine is a Schedule II
controlled substance available by prescription (Dexedrine®) and is also
available on the illicit market.Amphetamines area class of potent
sympathomimetic agents with therapeutic applications.They are chemically
related to the human body's natural catecholamines: epinephrine and
norepinephrine. Acute higher doses lead to enhanced stimulation of the central
nervous system and induce euphoria, alertness, reduced appetite, and a sense of
increased energy and power. Cardiovascular responses to Amphetamines include
increased blood pressure and cardiac arrhythmias. More acute responses produce
anxiety, paranoia, hallucinations, and psychotic behavior. The effects of
Amphetamines generally last 2-4 hours following use, and the drug has a
half-life of 4-24 hours in the body. About 30% of Amphetamines are excreted in
the urine in unchanged form, with the remainder as hydroxylated and deaminated
derivatives.
The DRUGCHECK® Drug of Abuse Test yields a positive
result when Amphetamines in urineexceed 1,000ng/mL.This is the suggested
screening cut-off for positive specimens set by the Substance Abuse and Mental
Health Services Administration (SAMHSA, USA). |
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